ABSTRACT
In the originally published version of this manuscript, 5 authors were inadvertently omitted: Dr Saad Islam, MBChB, Barts Health NHS Trust, Orthopaedics Dr Adil Hasnain MD, Barts Health NHS Trust, Orthopaedics Mr Shahanoor Ali, MBChB, Barts Health NHS Trust, Orthopaedics Mr Hassan Raja, MBChB, Barts Health NHS Trust, Orthopaedics Mr Konstantinos Tsitskaris, MD MSc FRCS(ortho), Barts Health NHS Trust, Orthopaedics This error has now been corrected.Copyright © The Author(s) 2022. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved.
ABSTRACT
In response to the COVID-19 outbreak, severe steps have been taken to control its rapid spread by countries globally. A nationwide lockdown was executed at the end of January 2020 in China, which resulted in a significant change and an improvement in air quality patterns. In this study, the objectives were to assess the spatiotemporal impact of the COVID-19 lockdown on air quality in Nanjing, China. The present study researched the six air pollutant parameters, namely, PM10, PM2.5, SO2, NO2, CO, and O-3. The data were divided into six periods, P1-P3: pre-lockdown, during lockdown, and after lockdown periods, P4-P6: 2017-19 (same dates of lockdown). The results reveal that during the COVID-19 control period, a significant drop and an improvement in air quality were observed. According to our findings, the PM10, PM2.5, SO2, NO2, and CO concentrations were reduced by -33.03%, -35.41%, -21.26%, -39.79%, and -20.65%, respectively, while the concentration of O-3 significantly increased by an average of 104.85% in Nanjing. From the previous 3 years to lockdown variations, PM10 (-40.60%), PM2.5 (-40.02%), SO2 (-54.19%), NO2 (-33.60%), and CO (23.16%) were also reduced, while O-3 increased (10.83%). Moreover, compared with those in the COVID-19 period, the levels of PM10, SO2, NO2, CO, and O-3 increased by 2.84%, 28.55%, 4.68%, 16.44%, and 37.36%, respectively, while PM2.5 reduced by up to -14.34% after the lockdown in Nanjing. The outcomes of our study provide a roadmap for the scientific community and local administration to make policies to control air pollution.
ABSTRACT
Jiangsu province is one of the economically strong provinces in east China. With the advance of the modernization process, the problem of air pollution in this area is facing a severe challenge under the common role of human activities and regional climate change. While the rest of the world struggles to control COVID-19, China has managed to control the pandemic rapidly and effectively with strong lockdown policies. This study investigates the change in air pollution (focusing on the air quality index (AQI), six ambient air pollutants nitrogen dioxide (NO2), ozone (O3), sulphur dioxide (SO2), carbon monoxide (CO), particulate matter with aerodynamic diameters ≤10 μm (PM10) and ≤2.5 μm (PM2.5)) patterns for different periods in last 5 years. Different pollutants have different behavior identified in this studied which is helping for understanding the pattern of air quality. Short-term health advantages from the COVID-19 pandemic can be attributed to the reduction in air pollution and significant improvement in ambient air quality, which need the government to enact post-COVID environmental regulations. © 2022, HARD Publishing Company. All rights reserved.
ABSTRACT
During the epidemic period, primary emissions across the world were significantly reduced, while the response to secondary pollution such as ozone differed from region to region. To study the impact of the strict control measures of the new COVID-19 epidemic on the air quality of Anhui in early 2020, the air quality monitoring data of Anhui, from 2019 to 2021, specifically 1 January to 30 August, was examined to analyze the characteristics of the temporal and spatial distribution. Regression and path analysis were used to extract the relationship between the variable. PM10 and O3, on average, increased by 6%, and 2%, while PM2.5, SO2 decreased by 15% and 10% in the post-COVID-19 period. All air quality pollutants decreased during the active-COVID-19 period, with a maximum decrease of 21% observed in PM10, followed by 19% of PM2.5, and a minimum decrease of 2% observed in O3 . Changes in air pollutants from 2017 to 2021 were also compared, and a decrease in all pollutants through 2020 was found. The air quality index (AQI) recorded a low decrease of 3% post-COVID-19, which shows that air quality will worsen in the future, but it decreased by 16% during the active-COVID-19 period. A path analysis model was developed to further understand the relationship between the AQI and air quality patterns. This path analysis shows a strong correlation between the AQI and PM10 and PM2.5, however, its correlation with other air pollutants is weak. Regression analysis shows a similar pattern of there being a strong relationship between AQI and PM10 (r2 = 0.97) and PM2.5 (r2 = 0.93). The government must implement policies to control the environmental issues which are causing poor air quality in post-COVID-19. © 2022, HARD Publishing Company. All rights reserved.
ABSTRACT
As the SARS-CoV-2 virus continues to mutate, global eradication of infections is unlikely, and COVID-19 is predicted to become a seasonal or endemic disease like influenza. Widespread detection of variant strains will be critical to inform policy decisions to mitigate further spread, and post-pandemic multiplexed screening of respiratory viruses will be necessary to properly manage patients presenting with similar respiratory symptoms. We have developed a portable, magnetofluidic platform for multiplexed PCR testing in <30 min. Cartridges were designed for multiplexed detection of SARS-CoV-2 with either distinctive variant mutations or with Influenza A and B and tested with clinical samples. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
ABSTRACT
Primary sclerosing cholangitis (PSC) is a cholestatic disorder wherein liver transplant is the definitive treatment for advance stages. However, recurrence of PSC after liver transplant is of concern which can leads to graft failure and may require retransplant. There is limited data on outcomes of living donor liver transplant (LDLT) in PSC. Also, in LDLT as donors are related there is possibility of disease recurrence. So, we conducted this retrospective study to analyse the outcomes of LDLT in PSC at a tertiary liver transplant centre in north India. Methods: We conducted a retrospective analysis of 3213 transplant recipients who underwent LDLT from January 2006 to May 2021. Of these 26 (0.80%) patients has PSC as indication for liver transplantation (PSC=24, PSC/AIH overlaP=2). Data analysis was done to look for baseline demographics, clinical details, transplant outcomes, PSC recurrence and survival. Results: Mean age of study group was 42(±13.8) years and 19 (73.1%) were males. All patients had decompensated cirrhosis at time of transplant. Mean CTP score and MELD score were 9.5(±1.8) and 18.9(±7.1) respectively. 16 patients received modified right lobe graft, 7 extended right lobe graft and 5 patients received left lateral graft. Average graft weight and GRWR were 633.5(IQR 473.5-633.5) grams and 1.23(SD±0.42) respectively. Most common biliary anastomosis was hepaticojejunostomy, done in 19(73.1%) while duct to duct anastomosis was performed in 7(26.9%) patients. Median follow- up was 96(36-123) months. One patient had ulcerative colitis and none had cholangiocarcinoma. Two (7.7%) patients had bile leak during early post-transplant period. Three (11.1%) patients developed graft rejection and managed successfully with steroid pulses. Three patients died during early post-transplant period while 7 deaths occurred during long term follow-up including one death due to COVID-19. Five (19.2%) patients had recurrence of PSC of which 2 patients lost their grafts including one after retransplantation. The overall 1 year and 5-year survival rates were 88.5% and 75% respectively. Conclusion: LDLT can be performed in PSC with good long-term outcomes with a risk of PSC recurrence in about 1/5th patients.
ABSTRACT
Background: Primary sclerosing cholangitis (PSC) is a cholestatic disorder wherein liver transplant is the definitive treatment for advance stages. However, recurrence of PSC after liver transplant is of concern which can leads to graft failure and may require retransplant. There is limited data on outcomes of living donor liver transplant (LDLT) in PSC. Also, in LDLT as donors are related there is possibility of disease recurrence. So, we conducted this retrospective study to analyze the outcomes of LDLT in PSC at a tertiary liver transplant centre in north India. Methods: We conducted a retrospective analysis of 3213 transplant recipients who underwent LDLT from January 2006 to May 2021. Of these 26 (0.80%) patients has PSC as indication for liver transplantation (PSC=24, PSC/AIH overlap=2). Data analysis was done to look for baseline demographics, clinical details, transplant outcomes, PSC recurrence and survival. Results: Mean age of study group was 42(±13.8) years and 19 (73.1%) were males. All patients had decompensated cirrhosis at time of transplant. Mean CTP score and MELD score were 9.5(±1.8) and 18.9(±7.1) respectively. 16 patients received modified right lobe graft, 7 extended right lobe graft and 5 patients received left lateral graft. Average graft weight and GRWR were 633.5(IQR 473.5-633.5) grams and 1.23(SD±0.42) respectively. Most common biliary anastomosis was hepaticojejunostomy, done in 19(73.1%) while duct to duct anastomosis was performed in 7(26.9%) patients. Median follow-up was 96(36-123) months. One patient had ulcerative colitis and none had cholangiocarcinoma. Two (7.7%) patients had bile leak during early post-transplant period. Three (11.1%) patients developed graft rejection and managed successfully with steroid pulses. Three patients died during early posttransplant period while 7 deaths occurred during long term follow-up including one death due to COVID-19. Five (19.2%) patients had recurrence of PSC of which 2 patients lost their grafts including one after retransplantation. The overall 1 year and 5-year survival rates were 88.5% and 75% respectively. Conclusion: LDLT can be performed in PSC with good longterm outcomes with a risk of PSC recurrence in about 1/5th patients.